Decreased Striatal RGS2 Expression Is Neuroprotective in Huntington's Disease (HD) and Exemplifies a Compensatory Aspect of HD-Induced Gene Regulation

BACKGROUND: The molecular phenotype of Huntington's disease (HD) is known to comprise highly reproducible changes in gene expression involving striatal signaling genes. Here we test whether individual changes in striatal gene expression are capable of mitigating HD-related neurotoxicity. METHOD...

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Detalles Bibliográficos
Autores principales: Seredenina, Tamara, Gokce, Ozgun, Luthi-Carter, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136499/
https://www.ncbi.nlm.nih.gov/pubmed/21779398
http://dx.doi.org/10.1371/journal.pone.0022231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136499/
https://www.ncbi.nlm.nih.gov/pubmed/21779398
http://dx.doi.org/10.1371/journal.pone.0022231

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