Proton Pump Inhibitors Inhibit Metformin Uptake by Organic Cation Transporters (OCTs)

Metformin, an oral insulin-sensitizing drug, is actively transported into cells by organic cation transporters (OCT) 1, 2, and 3 (encoded by SLC22A1, SLC22A2, or SLC22A3), which are tissue specifically expressed at significant levels in various organs such as liver, muscle, and kidney. Because metfo...

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Detalles Bibliográficos
Autores principales: Nies, Anne T., Hofmann, Ute, Resch, Claudia, Schaeffeler, Elke, Rius, Maria, Schwab, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136501/
https://www.ncbi.nlm.nih.gov/pubmed/21779389
http://dx.doi.org/10.1371/journal.pone.0022163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136501/
https://www.ncbi.nlm.nih.gov/pubmed/21779389
http://dx.doi.org/10.1371/journal.pone.0022163

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