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Proton Pump Inhibitors Inhibit Metformin Uptake by Organic Cation Transporters (OCTs)
Metformin, an oral insulin-sensitizing drug, is actively transported into cells by organic cation transporters (OCT) 1, 2, and 3 (encoded by SLC22A1, SLC22A2, or SLC22A3), which are tissue specifically expressed at significant levels in various organs such as liver, muscle, and kidney. Because metfo...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136501/ https://www.ncbi.nlm.nih.gov/pubmed/21779389 http://dx.doi.org/10.1371/journal.pone.0022163 |