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Herbal Medicine Containing Licorice May Be Contraindicated for a Patient with an HSD11B2 Mutation
Licorice ingestion, as well as mutations in the HSD11B2 gene, inhibits 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) enzyme activity, causing the syndrome of apparent mineral corticoid excess (AME). However, the combined effect of licorice ingestion and an HSD11B2 mutation has never been reporte...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136776/ https://www.ncbi.nlm.nih.gov/pubmed/20007258 http://dx.doi.org/10.1093/ecam/nep211 |
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author | Harahap, Indra Sari Kusuma Sasaki, Naoko Gunadi, Yusoff, Surini Lee, Myeong Jin Morikawa, Satoru Nishimura, Noriyuki Sasaki, Tomohiro Usuki, Seiichiro Hirai, Midori Ohta, Mika Takaoka, Yutaka Nishimoto, Takashi Nishio, Hisahide |
author_facet | Harahap, Indra Sari Kusuma Sasaki, Naoko Gunadi, Yusoff, Surini Lee, Myeong Jin Morikawa, Satoru Nishimura, Noriyuki Sasaki, Tomohiro Usuki, Seiichiro Hirai, Midori Ohta, Mika Takaoka, Yutaka Nishimoto, Takashi Nishio, Hisahide |
author_sort | Harahap, Indra Sari Kusuma |
collection | PubMed |
description | Licorice ingestion, as well as mutations in the HSD11B2 gene, inhibits 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) enzyme activity, causing the syndrome of apparent mineral corticoid excess (AME). However, the combined effect of licorice ingestion and an HSD11B2 mutation has never been reported, until now. In this study, we demonstrated that licorice ingestion can produce overt hypertension in an individual without medical history of hypertension who is heterozygous for wild-type and mutant HSD11B2 genes. Our patient was a 51-year-old female with serious hypertension who had been taking herbal medicine containing licorice for more than one year. She was clinically diagnosed as having licorice intoxication, because she did not present with hypertension after ceasing the herbal medicine. Molecular analysis showed that she carried a missense mutation, c.40C>T, in HSD11B2. In conclusion, licorice ingestion is an environmental risk factor for hypertension or AME state in patients with a mutation in HSD11B2. Carrying a mutation in HSD11B2 is, conversely, a genetic risk factor for licorice-induced hypertension or AME state. Herbal medicine containing licorice may, therefore, be contraindicated in patients with an HSD11B2 mutation. |
format | Online Article Text |
id | pubmed-3136776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31367762011-07-28 Herbal Medicine Containing Licorice May Be Contraindicated for a Patient with an HSD11B2 Mutation Harahap, Indra Sari Kusuma Sasaki, Naoko Gunadi, Yusoff, Surini Lee, Myeong Jin Morikawa, Satoru Nishimura, Noriyuki Sasaki, Tomohiro Usuki, Seiichiro Hirai, Midori Ohta, Mika Takaoka, Yutaka Nishimoto, Takashi Nishio, Hisahide Evid Based Complement Alternat Med Case Report Licorice ingestion, as well as mutations in the HSD11B2 gene, inhibits 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) enzyme activity, causing the syndrome of apparent mineral corticoid excess (AME). However, the combined effect of licorice ingestion and an HSD11B2 mutation has never been reported, until now. In this study, we demonstrated that licorice ingestion can produce overt hypertension in an individual without medical history of hypertension who is heterozygous for wild-type and mutant HSD11B2 genes. Our patient was a 51-year-old female with serious hypertension who had been taking herbal medicine containing licorice for more than one year. She was clinically diagnosed as having licorice intoxication, because she did not present with hypertension after ceasing the herbal medicine. Molecular analysis showed that she carried a missense mutation, c.40C>T, in HSD11B2. In conclusion, licorice ingestion is an environmental risk factor for hypertension or AME state in patients with a mutation in HSD11B2. Carrying a mutation in HSD11B2 is, conversely, a genetic risk factor for licorice-induced hypertension or AME state. Herbal medicine containing licorice may, therefore, be contraindicated in patients with an HSD11B2 mutation. Hindawi Publishing Corporation 2011 2011-02-20 /pmc/articles/PMC3136776/ /pubmed/20007258 http://dx.doi.org/10.1093/ecam/nep211 Text en Copyright © 2011 Indra Sari Kusuma Harahap et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Harahap, Indra Sari Kusuma Sasaki, Naoko Gunadi, Yusoff, Surini Lee, Myeong Jin Morikawa, Satoru Nishimura, Noriyuki Sasaki, Tomohiro Usuki, Seiichiro Hirai, Midori Ohta, Mika Takaoka, Yutaka Nishimoto, Takashi Nishio, Hisahide Herbal Medicine Containing Licorice May Be Contraindicated for a Patient with an HSD11B2 Mutation |
title | Herbal Medicine Containing Licorice May Be Contraindicated for a Patient with an HSD11B2 Mutation |
title_full | Herbal Medicine Containing Licorice May Be Contraindicated for a Patient with an HSD11B2 Mutation |
title_fullStr | Herbal Medicine Containing Licorice May Be Contraindicated for a Patient with an HSD11B2 Mutation |
title_full_unstemmed | Herbal Medicine Containing Licorice May Be Contraindicated for a Patient with an HSD11B2 Mutation |
title_short | Herbal Medicine Containing Licorice May Be Contraindicated for a Patient with an HSD11B2 Mutation |
title_sort | herbal medicine containing licorice may be contraindicated for a patient with an hsd11b2 mutation |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136776/ https://www.ncbi.nlm.nih.gov/pubmed/20007258 http://dx.doi.org/10.1093/ecam/nep211 |
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