Protective Immunity Induced with the RTS,S/AS Vaccine Is Associated with IL-2 and TNF-α Producing Effector and Central Memory CD4(+) T Cells

A phase 2a RTS,S/AS malaria vaccine trial, conducted previously at the Walter Reed Army Institute of Research, conferred sterile immunity against a primary challenge with infectious sporozoites in 40% of the 80 subjects enrolled in the study. The frequency of Plasmodium falciparum circumsporozoite p...

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Detalles Bibliográficos
Autores principales: Lumsden, Joanne M., Schwenk, Robert J., Rein, Lisa E., Moris, Philippe, Janssens, Michel, Ofori-Anyinam, Opokua, Cohen, Joe, Kester, Kent E., Heppner, D. Gray, Krzych, Urszula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136919/
https://www.ncbi.nlm.nih.gov/pubmed/21779319
http://dx.doi.org/10.1371/journal.pone.0020775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136919/
https://www.ncbi.nlm.nih.gov/pubmed/21779319
http://dx.doi.org/10.1371/journal.pone.0020775

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