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Identification of Selective Agonists and Antagonists to G Protein-Activated Inwardly Rectifying Potassium Channels: Candidate Medicines for Drug Dependence and Pain

G protein-activated inwardly rectifying K(+) (GIRK) channels have been known to play a key role in the rewarding and analgesic effects of opioids. To identify potent agonists and antagonists to GIRK channels, we examined various compounds for their ability to activate or inhibit GIRK channels. A tot...

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Detalles Bibliográficos
Autores principales: Nishizawa, D, Gajya, N, Ikeda, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd. 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137163/
https://www.ncbi.nlm.nih.gov/pubmed/21886574
http://dx.doi.org/10.2174/157015911795017227