Stereochemical Basis for Engineered Pyrrolysyl-tRNA Synthetase and the Efficient in Vivo Incorporation of Structurally Divergent Non-native Amino Acids

[Image: see text] Unnatural amino acids (Uaas) can be translationally incorporated into proteins in vivo using evolved tRNA/aminoacyl-tRNA synthetase (RS) pairs, affording chemistries inaccessible when restricted to the 20 natural amino acids. To date, most evolved RSs aminoacylate Uaas chemically s...

Descripción completa

Detalles Bibliográficos
Autores principales: Takimoto, Jeffrey K., Dellas, Nikki, Noel, Joseph P., Wang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137230/
https://www.ncbi.nlm.nih.gov/pubmed/21545173
http://dx.doi.org/10.1021/cb200057a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137230/
https://www.ncbi.nlm.nih.gov/pubmed/21545173
http://dx.doi.org/10.1021/cb200057a

Ejemplares similares