Cargando…

Stereochemical Basis for Engineered Pyrrolysyl-tRNA Synthetase and the Efficient in Vivo Incorporation of Structurally Divergent Non-native Amino Acids

[Image: see text] Unnatural amino acids (Uaas) can be translationally incorporated into proteins in vivo using evolved tRNA/aminoacyl-tRNA synthetase (RS) pairs, affording chemistries inaccessible when restricted to the 20 natural amino acids. To date, most evolved RSs aminoacylate Uaas chemically s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Takimoto, Jeffrey K., Dellas, Nikki, Noel, Joseph P., Wang, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2011
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137230/ https://www.ncbi.nlm.nih.gov/pubmed/21545173 http://dx.doi.org/10.1021/cb200057a

Ejemplares similares

Genetic Incorporation of Histidine Derivatives Using an Engineered Pyrrolysyl-tRNA Synthetase
por: Xiao, Han, et al.
Publicado: (2014)

Engineering Pyrrolysyl-tRNA Synthetase for the Incorporation of Non-Canonical Amino Acids with Smaller Side Chains
por: Koch, Nikolaj G., et al.
Publicado: (2021)

Pyrrolysyl-tRNA synthetase:tRNA(Pyl) structure reveals the molecular basis of orthogonality
por: Nozawa, Kayo, et al.
Publicado: (2008)

Ferritin Conjugates With Multiple Clickable Amino Acids Encoded by C-Terminal Engineered Pyrrolysyl-tRNA Synthetase
por: Wang, Yi-Hui, et al.
Publicado: (2021)

Expanding the Genetic Code of Yeast for Incorporation of Diverse Unnatural Amino Acids via a Pyrrolysyl-tRNA Synthetase/tRNA Pair
por: Hancock, Susan M., et al.
Publicado: (2010)

Efficient Multisite Unnatural Amino Acid Incorporation in Mammalian Cells via Optimized Pyrrolysyl tRNA Synthetase/tRNA Expression and Engineered eRF1
por: Schmied, Wolfgang H., et al.
Publicado: (2014)

Recognition of pyrrolysine tRNA by the Desulfitobacterium hafniense pyrrolysyl-tRNA synthetase
por: Herring, Stephanie, et al.
Publicado: (2007)

Quintuply orthogonal pyrrolysyl-tRNA synthetase/tRNA(Pyl) pairs
por: Beattie, Adam T., et al.
Publicado: (2023)

Expanding the Scope of Orthogonal Translation with Pyrrolysyl-tRNA Synthetases Dedicated to Aromatic Amino Acids
por: Tseng, Hsueh-Wei, et al.
Publicado: (2020)

Transferability of N-terminal mutations of pyrrolysyl-tRNA synthetase in one species to that in another species on unnatural amino acid incorporation efficiency
por: Williams, Thomas L., et al.
Publicado: (2020)

Engineering a Polyspecific Pyrrolysyl-tRNA Synthetase by a High Throughput FACS Screen
por: Hohl, Adrian, et al.
Publicado: (2019)

Chimeric design of pyrrolysyl-tRNA synthetase/tRNA pairs and canonical synthetase/tRNA pairs for genetic code expansion
por: Ding, Wenlong, et al.
Publicado: (2020)

Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA synthetase
por: Suzuki, Tateki, et al.
Publicado: (2017)

Methanomethylophilus alvus Mx1201 Provides Basis for Mutual Orthogonal Pyrrolysyl tRNA/Aminoacyl-tRNA Synthetase Pairs in Mammalian Cells
por: Meineke, Birthe, et al.
Publicado: (2018)

Linker and N-Terminal Domain Engineering of Pyrrolysyl-tRNA Synthetase for Substrate Range Shifting and Activity Enhancement
por: Jiang, Han-Kai, et al.
Publicado: (2020)

Rapid Identification of Functional Pyrrolysyl-tRNA Synthetases via Fluorescence-Activated Cell Sorting
por: Lin, Andrew E., et al.
Publicado: (2018)

Efficient Unnatural Protein Production by Pyrrolysyl-tRNA Synthetase With Genetically Fused Solubility Tags
por: Koch, Nikolaj G., et al.
Publicado: (2021)

An Evolved Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetase/tRNA Pair Is Highly Active and Orthogonal in Mammalian Cells
por: Beránek, Václav, et al.
Publicado: (2018)

The tRNA discriminator base defines the mutual orthogonality of two distinct pyrrolysyl-tRNA synthetase/tRNA(Pyl) pairs in the same organism
por: Zhang, Haolin, et al.
Publicado: (2022)

Pyrrolysyl-tRNA Synthetase with a Unique Architecture Enhances the Availability of Lysine Derivatives in Synthetic Genetic Codes
por: Yamaguchi, Atsushi, et al.
Publicado: (2018)

Directed Evolution of Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetase Generates a Hyperactive and Highly Selective Variant
por: Fischer, Jonathan T., et al.
Publicado: (2022)

Directed Evolution of the Methanosarcina barkeri Pyrrolysyl tRNA/aminoacyl tRNA Synthetase Pair for Rapid Evaluation of Sense Codon Reassignment Potential
por: Schwark, David G., et al.
Publicado: (2021)

Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase enzymes to include non-α-amino acids in vitro and in vivo
por: Fricke, Riley, et al.
Publicado: (2023)

Enhancing the performance of a mutant pyrrolysyl-tRNA synthetase to create a highly versatile eukaryotic cell-free protein synthesis tool
por: Schloßhauer, Jeffrey L., et al.
Publicado: (2023)

The structural basis of the genetic code: amino acid recognition by aminoacyl-tRNA synthetases
por: Kaiser, Florian, et al.
Publicado: (2020)

Structural basis for the dynamics of human methionyl-tRNA synthetase in multi-tRNA synthetase complexes
por: Kim, Dong Kyu, et al.
Publicado: (2021)

Nonsense and Sense Suppression Abilities of Original and Derivative Methanosarcina mazei Pyrrolysyl-tRNA Synthetase-tRNA(Pyl) Pairs in the Escherichia coli BL21(DE3) Cell Strain
por: Odoi, Keturah A., et al.
Publicado: (2013)

Crystal Structure of Pyrrolysyl-tRNA Synthetase from a Methanogenic Archaeon ISO4-G1 and Its Structure-Based Engineering for Highly-Productive Cell-Free Genetic Code Expansion with Non-Canonical Amino Acids
por: Yanagisawa, Tatsuo, et al.
Publicado: (2023)

Ancient origin of the divergent forms of leucyl-tRNA synthetases in the Halobacteriales
por: Andam, Cheryl P, et al.
Publicado: (2012)

Structural basis for recognition of G-1-containing tRNA by histidyl-tRNA synthetase
por: Tian, Qingnan, et al.
Publicado: (2015)

Structural Basis for the Antibiotic Resistance of Eukaryotic Isoleucyl-tRNA Synthetase
por: Chung, Scisung, et al.
Publicado: (2020)

Study of the Binding Energies between Unnatural Amino Acids and Engineered Orthogonal Tyrosyl-tRNA Synthetases
por: Ren, Wei, et al.
Publicado: (2015)

Change of tRNA identity leads to a divergent orthogonal histidyl-tRNA synthetase/tRNA(His) pair
por: Yuan, Jing, et al.
Publicado: (2011)

Structural basis for recognition of cognate tRNA by tyrosyl-tRNA synthetase from three kingdoms
por: Tsunoda, Masaru, et al.
Publicado: (2007)

Minimizing the Anticodon-Recognized Loop of Methanococcus jannaschii Tyrosyl-tRNA Synthetase to Improve the Efficiency of Incorporating Noncanonical Amino Acids
por: Hu, Zhiyang, et al.
Publicado: (2023)

Structural basis of a two-step tRNA recognition mechanism for plastid glycyl-tRNA synthetase
por: Yu, Zhaoli, et al.
Publicado: (2023)

Structure of human tryptophanyl-tRNA synthetase in complex with tRNA(Trp) reveals the molecular basis of tRNA recognition and specificity
por: Shen, Ning, et al.
Publicado: (2006)

Bacterial Aspartyl-tRNA Synthetase Has Glutamyl-tRNA Synthetase Activity
por: Rathnayake, Udumbara M., et al.
Publicado: (2019)

Aminoacyl-tRNA synthetases of the multi-tRNA synthetase complex and their role in tumorigenesis
por: Khan, Krishnendu, et al.
Publicado: (2022)

Aminoacyl-tRNA synthetases
por: Rubio Gomez, Miguel Angel, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_b39m7o0j7h4lkhclbn8f8ma2gh