Screening for GPCR Ligands Using Surface Plasmon Resonance

[Image: see text] G-protein coupled receptors (GPCRs) are a class of drug targets of primary importance. However, receptor assays are based on measurement of either ligand displacement or downstream functional responses, rather than direct observation of ligand binding. Issues of allosteric modulati...

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Detalles Bibliográficos
Autores principales: Navratilova, Iva, Besnard, Jérémy, Hopkins, Andrew L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137231/
https://www.ncbi.nlm.nih.gov/pubmed/21765967
http://dx.doi.org/10.1021/ml2000017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137231/
https://www.ncbi.nlm.nih.gov/pubmed/21765967
http://dx.doi.org/10.1021/ml2000017

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