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Screening for GPCR Ligands Using Surface Plasmon Resonance
[Image: see text] G-protein coupled receptors (GPCRs) are a class of drug targets of primary importance. However, receptor assays are based on measurement of either ligand displacement or downstream functional responses, rather than direct observation of ligand binding. Issues of allosteric modulati...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137231/ https://www.ncbi.nlm.nih.gov/pubmed/21765967 http://dx.doi.org/10.1021/ml2000017 |