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Dysregulated ΔNp63α Inhibits Expression of Ink4a/arf, Blocks Senescence, and Promotes Malignant Conversion of Keratinocytes

p63 is critical for squamous epithelial development, and elevated levels of the ΔNp63α isoform are seen in squamous cell cancers of various organ sites. However, significant controversy exists regarding the role of p63 isoforms as oncoproteins or tumor suppressors. Here, lentiviruses were developed...

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Detalles Bibliográficos
Autores principales: Ha, Linan, Ponnamperuma, Roshini M., Jay, Steven, Ricci, M. Stacey, Weinberg, Wendy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137598/
https://www.ncbi.nlm.nih.gov/pubmed/21789189
http://dx.doi.org/10.1371/journal.pone.0021877