Cargando…

Effect of Steric Constraint at the γ-Backbone Position on the Conformations and Hybridization Properties of PNAs

Conformationally preorganized peptide nucleic acids (PNAs) have been synthesized through backbone modifications at the γ-position, where R = alanine, valine, isoleucine, and phenylalanine side chains. The effects of these side-chains on the conformations and hybridization properties of PNAs were det...

Descripción completa

Detalles Bibliográficos
Autores principales:	Crawford, Matthew J., Rapireddy, Srinivas, Bahal, Raman, Sacui, Iulia, Ly, Danith H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE-Hindawi Access to Research 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138043/ https://www.ncbi.nlm.nih.gov/pubmed/21776375 http://dx.doi.org/10.4061/2011/652702

Ejemplares similares

Anti-tumor Activity of miniPEG-γ-Modified PNAs to Inhibit MicroRNA-210 for Cancer Therapy
por: Gupta, Anisha, et al.
Publicado: (2017)

Quantifying the role of steric constraints in nucleosome positioning
por: Rube, H. Tomas, et al.
Publicado: (2014)

Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy
por: Wang, Yazhe, et al.
Publicado: (2023)

Integrative Assembly of Heteroleptic Tetrahedra Controlled by Backbone Steric Bulk
por: Tessarolo, Jacopo, et al.
Publicado: (2021)

Introducing PNAS Nexus
por: Nelson, Karen, et al.
Publicado: (2022)

Welcome, PNAS Nexus!
por: McNutt, Marcia
Publicado: (2022)

Inhibition of 5′-UTR RNA Conformational Switching in HIV-1 Using Antisense PNAs
por: Parkash, Braham, et al.
Publicado: (2012)

Correction of F508del CFTR in airway epithelium using nanoparticles delivering triplex-forming PNAs
por: McNeer, Nicole Ali, et al.
Publicado: (2015)

Adaptation and constraint in the evolution of the mammalian backbone
por: Jones, Katrina E., et al.
Publicado: (2018)

Happy first birthday, PNAS Nexus
Publicado: (2023)

Mercury(II) Complexes of Anionic N-Heterocyclic Carbene Ligands: Steric Effects of the Backbone Substituent
por: Dash, Chandrakanta, et al.
Publicado: (2020)

PNAS establishes a Statistical Review Committee
por: Raftery, Adrian E., et al.
Publicado: (2023)

Cu(2+)-based distance measurements by pulsed EPR provide distance constraints for DNA backbone conformations in solution
por: Ghosh, Shreya, et al.
Publicado: (2020)

In search of visible-light photoresponsive peptide nucleic acids (PNAs) for reversible control of DNA hybridization
por: Zhang, Lei, et al.
Publicado: (2019)

Steric Repulsion Induced Conformational Switch in Supramolecular Structures
por: Norvaiša, Karolis, et al.
Publicado: (2021)

Duplex DNA-Invading γ-Modified Peptide Nucleic Acids Enable Rapid Identification of Bloodstream Infections in Whole Blood
por: Nölling, Jörk, et al.
Publicado: (2016)

Systematic Differences in Impact across Publication Tracks at PNAS
por: Rand, David G., et al.
Publicado: (2009)

Species-Selective Killing of Bacteria by Antimicrobial Peptide-PNAs
por: Mondhe, Madhav, et al.
Publicado: (2014)

PNAS rebrand: Improving accessibility in its many forms
por: Berenbaum, May R.
Publicado: (2022)

Correction to: Volume 2 Issue 1 of PNAS Nexus
Publicado: (2023)

Steric exclusion and constraint satisfaction in multi-scale coarse-grained simulations
por: Taylor, William R.
Publicado: (2016)

Solid-Phase Synthesis of Difficult Purine-Rich PNAs through Selective Hmb Incorporation: Application to the Total Synthesis of Cell Penetrating Peptide-PNAs
por: Tailhades, Julien, et al.
Publicado: (2017)

Non-steric-zipper models for pathogenic α-synuclein conformers
por: Schuman, Brock, et al.
Publicado: (2018)

London Dispersion Favors Sterically Hindered Diarylthiourea Conformers in Solution
por: Rummel, Lars, et al.
Publicado: (2022)

Helix control in polymers: Case of peptide nucleic acids (PNAs)
por: Totsingan, Filbert, et al.
Publicado: (2012)

Ultrasound-assisted Peptide Nucleic Acids synthesis (US-PNAS)
por: Del Bene, Alessandra, et al.
Publicado: (2023)

CRANKITE: A fast polypeptide backbone conformation sampler
por: Podtelezhnikov, Alexei A, et al.
Publicado: (2008)

Bis(oxazolines) based on glycopyranosides – steric, configurational and conformational influences on stereoselectivity
por: Minuth, Tobias, et al.
Publicado: (2010)

Mapping the Conformational Dynamics and Pathways of Spontaneous Steric Zipper Peptide Oligomerization
por: Matthes, Dirk, et al.
Publicado: (2011)

Steric exclusion and protein conformation determine the localization of plasma membrane transporters
por: Bianchi, Frans, et al.
Publicado: (2018)

2,3;5,6-Di-O-isopropylidene-1-O-(2-phenylacetyl)-α-d-mannofuranose
por: Sacui, Iulia A., et al.
Publicado: (2010)

The function of tcf3 in medaka embryos: efficient knockdown with pePNAs
por: Doenz, Gerlinde, et al.
Publicado: (2018)

Backbone Conformational Equilibrium in Mismatched DNA Correlates with Enzyme Activity
por: Westwood, M. N., et al.
Publicado: (2023)

Anti‐cooperative Self‐Assembly with Maintained Emission Regulated by Conformational and Steric Effects
por: Helmers, Ingo, et al.
Publicado: (2022)

Unexpected Nucleophile Masking in Acyl Transfer to Sterically Crowded and Conformationally Restricted Galactosides
por: Sukhran, Yonatan, et al.
Publicado: (2023)

Stratification relieves constraints from steric hindrance in the generation of compact actomyosin asters at the membrane cortex
por: Das, Amit, et al.
Publicado: (2020)

Identification, Characterization, and Effects of Xenopus laevis PNAS-4 Gene on Embryonic Development
por: Yan, Fei, et al.
Publicado: (2010)

Polyanionic Carboxyethyl Peptide Nucleic Acids (ce-PNAs): Synthesis and DNA Binding
por: Kirillova, Yuliya, et al.
Publicado: (2015)

Influence of Different Cell-Penetrating Peptides on the Antimicrobial Efficiency of PNAs in Streptococcus pyogenes
por: Barkowsky, Gina, et al.
Publicado: (2019)

Visible-light triggered templated ligation on surface using furan-modified PNAs
por: Manicardi, Alex, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_l77j0ths9l2vflocvj7ia6gmdo