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Inhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion

Host cyclophilin (cyp) inhibitors, such as NIM811, efficiently inhibit replication of hepatitis C virus (HCV) and have shown significant promise in recent clinical trials for the treatment of chronic HCV. It is therefore important to fully understand the mechanism of action of these therapeutic agen...

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Detalles Bibliográficos
Autores principales: Anderson, Leah J, Lin, Kai, Compton, Teresa, Wiedmann, Brigitte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138436/
https://www.ncbi.nlm.nih.gov/pubmed/21711559
http://dx.doi.org/10.1186/1743-422X-8-329