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Small molecule displacement of a cryptic degron causes conditional protein degradation

The ability to rapidly regulate the functions of specific proteins in living cells is a valuable tool for biological research. Here we describe a novel technique by which the degradation of a specific protein is induced by a small molecule. A protein of interest is fused to a Ligand-Induced Degradat...

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Detalles Bibliográficos
Autores principales: Bonger, Kimberly M., Chen, Ling-chun, Liu, Corey W., Wandless, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139708/
https://www.ncbi.nlm.nih.gov/pubmed/21725303
http://dx.doi.org/10.1038/nchembio.598