Small-Molecule Hydrophobic Tagging Induced Degradation of HaloTag Fusion Proteins

The ability to regulate any protein of interest in living systems with small molecules remains a challenge. We hypothesized that appending a hydrophobic moiety to the surface of a protein would mimic the partially denatured state of the protein, thus engaging the cellular quality control machinery t...

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Detalles Bibliográficos
Autores principales: Neklesa, Taavi K., Tae, Hyun Seop, Schneekloth, Ashley R., Stulberg, Michael J., Corson, Timothy W., Sundberg, Thomas B., Raina, Kanak, Holley, Scott A., Crews, Craig M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139752/
https://www.ncbi.nlm.nih.gov/pubmed/21725302
http://dx.doi.org/10.1038/nchembio.597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139752/
https://www.ncbi.nlm.nih.gov/pubmed/21725302
http://dx.doi.org/10.1038/nchembio.597

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