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Small-Molecule Hydrophobic Tagging Induced Degradation of HaloTag Fusion Proteins
The ability to regulate any protein of interest in living systems with small molecules remains a challenge. We hypothesized that appending a hydrophobic moiety to the surface of a protein would mimic the partially denatured state of the protein, thus engaging the cellular quality control machinery t...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139752/ https://www.ncbi.nlm.nih.gov/pubmed/21725302 http://dx.doi.org/10.1038/nchembio.597 |