Structural Basis of Regiospecificity of a Mononuclear Iron Enzyme in Antibiotic Fosfomycin Biosynthesis

[Image: see text] Hydroxypropylphosphonic acid epoxidase (HppE) is an unusual mononuclear iron enzyme that uses dioxygen to catalyze the oxidative epoxidation of (S)-2-hydroxypropylphosphonic acid (S-HPP) in the biosynthesis of the antibiotic fosfomycin. Additionally, the enzyme converts the R-enant...

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Detalles Bibliográficos
Autores principales: Yun, Danny, Dey, Mishtu, Higgins, Luke J., Yan, Feng, Liu, Hung-wen, Drennan, Catherine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140168/
https://www.ncbi.nlm.nih.gov/pubmed/21682308
http://dx.doi.org/10.1021/ja2025728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140168/
https://www.ncbi.nlm.nih.gov/pubmed/21682308
http://dx.doi.org/10.1021/ja2025728

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