An Engineered Viral Protease Exhibiting Substrate Specificity for a Polyglutamine Stretch Prevents Polyglutamine-Induced Neuronal Cell Death

BACKGROUND: Polyglutamine (polyQ)-induced protein aggregation is the hallmark of a group of neurodegenerative diseases, including Huntington's disease. We hypothesized that a protease that could cleave polyQ stretches would intervene in the initial events leading to pathogenesis in these diseas...

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Detalles Bibliográficos
Autores principales: Sellamuthu, Saravanan, Shin, Bae Hyun, Han, Hye-Eun, Park, Sang Min, Oh, Hye Jin, Rho, Seong-Hwan, Lee, Yong Jae, Park, Woo Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140514/
https://www.ncbi.nlm.nih.gov/pubmed/21799895
http://dx.doi.org/10.1371/journal.pone.0022554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140514/
https://www.ncbi.nlm.nih.gov/pubmed/21799895
http://dx.doi.org/10.1371/journal.pone.0022554

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