Perforin pores in the endosomal membrane trigger release of endocytosed granzyme B to the cytosol of target cells

How the pore-forming protein perforin delivers apoptosis-inducing granzymes to the cytosol of target cells is uncertain. Perforin induces a transient Ca(2+) flux in the target, which triggers a damaged cell membrane repair process. As a consequence, both perforin and granzymes are endocytosed into e...

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Detalles Bibliográficos
Autores principales: Thiery, Jerome, Keefe, Dennis, Boulant, Steeve, Boucrot, Emmanuel, Walch, Michael, Martinvalet, Denis, Goping, Ing Swie, Bleackley, R. Chris, Kirchhausen, Tomas, Lieberman, Judy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140544/
https://www.ncbi.nlm.nih.gov/pubmed/21685908
http://dx.doi.org/10.1038/ni.2050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140544/
https://www.ncbi.nlm.nih.gov/pubmed/21685908
http://dx.doi.org/10.1038/ni.2050

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