The G1613A Mutation in the HBV Genome Affects HBeAg Expression and Viral Replication through Altered Core Promoter Activity

Infection of hepatitis B virus (HBV) causes acute and chronic hepatitis and is closely associated with the development of cirrhosis and hepatocellular carcinoma (HCC). Previously, we demonstrated that the G1613A mutation in the HBV negative regulatory element (NRE) is a hotspot mutation in HCC patie...

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Detalles Bibliográficos
Autores principales: Li, Man-Shan, Lau, Terrence Chi-Kong, Chan, Sophie Ka-Ping, Wong, Chi-Hang, Ng, Patrick Kwok-Shing, Sung, Joseph Jao-Yiu, Chan, Henry Lik-Yuen, Tsui, Stephen Kwok-Wing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140978/
https://www.ncbi.nlm.nih.gov/pubmed/21814558
http://dx.doi.org/10.1371/journal.pone.0021856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140978/
https://www.ncbi.nlm.nih.gov/pubmed/21814558
http://dx.doi.org/10.1371/journal.pone.0021856

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