Characterization of the Channel Constriction Allowing the Access of the Substrate to the Active Site of Yeast Oxidosqualene Cyclase

In oxidosqualene cyclases (OSCs), an enzyme which has been extensively studied as a target for hypocholesterolemic or antifungal drugs, a lipophilic channel connects the surface of the protein with the active site cavity. Active site and channel are separated by a narrow constriction operating as a...

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Detalles Bibliográficos
Autores principales: Oliaro-Bosso, Simonetta, Caron, Giulia, Taramino, Silvia, Ermondi, Giuseppe, Viola, Franca, Balliano, Gianni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141018/
https://www.ncbi.nlm.nih.gov/pubmed/21811565
http://dx.doi.org/10.1371/journal.pone.0022134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141018/
https://www.ncbi.nlm.nih.gov/pubmed/21811565
http://dx.doi.org/10.1371/journal.pone.0022134

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