(13)C Metabolic Flux Analysis Identifies an Unusual Route for Pyruvate Dissimilation in Mycobacteria which Requires Isocitrate Lyase and Carbon Dioxide Fixation

Mycobacterium tuberculosis requires the enzyme isocitrate lyase (ICL) for growth and virulence in vivo. The demonstration that M. tuberculosis also requires ICL for survival during nutrient starvation and has a role during steady state growth in a glycerol limited chemostat indicates a function for...

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Detalles Bibliográficos
Autores principales: Beste, Dany J. V., Bonde, Bhushan, Hawkins, Nathaniel, Ward, Jane L., Beale, Michael H., Noack, Stephan, Nöh, Katharina, Kruger, Nicholas J., Ratcliffe, R. George, McFadden, Johnjoe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141028/
https://www.ncbi.nlm.nih.gov/pubmed/21814509
http://dx.doi.org/10.1371/journal.ppat.1002091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141028/
https://www.ncbi.nlm.nih.gov/pubmed/21814509
http://dx.doi.org/10.1371/journal.ppat.1002091

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