Cargando…

Acute Vhl Gene Inactivation Induces Cardiac HIF-Dependent Erythropoietin Gene Expression

Von Hippel Lindau (Vhl) gene inactivation results in embryonic lethality. The consequences of its inactivation in adult mice, and of the ensuing activation of the hypoxia-inducible factors (HIFs), have been explored mainly in a tissue-specific manner. This mid-gestation lethality can be also circumv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Miró-Murillo, Marta, Elorza, Ainara, Soro-Arnáiz, Inés, Albacete-Albacete, Lucas, Ordoñez, Angel, Balsa, Eduardo, Vara-Vega, Alicia, Vázquez, Silvia, Fuertes, Esther, Fernández-Criado, Carmen, Landázuri, Manuel O., Aragonés, Julián
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141062/ https://www.ncbi.nlm.nih.gov/pubmed/21811636 http://dx.doi.org/10.1371/journal.pone.0022589

Ejemplares similares

The VHL gene is epigenetically inactivated in pheochromocytomas and abdominal paragangliomas
por: Andreasson, Adam, et al.
Publicado: (2013)

Playing Tag with HIF: The VHL Story
por: Leung, Sherri K., et al.
Publicado: (2002)

VHL-P138R and VHL-L163R Novel Variants: Mechanisms of VHL Pathogenicity Involving HIF-Dependent and HIF-Independent Actions
por: Mathó, Cecilia, et al.
Publicado: (2022)

Renal Tubular HIF-2α Expression Requires VHL Inactivation and Causes Fibrosis and Cysts
por: Schietke, Ruth E., et al.
Publicado: (2012)

VHL and Hypoxia Signaling: Beyond HIF in Cancer
por: Zhang, Jing, et al.
Publicado: (2018)

VHL Type 2B gene mutation moderates HIF dosage in vitro and in vivo
por: Lee, C M, et al.
Publicado: (2009)

Deciphering von Hippel-Lindau (VHL/Vhl)-Associated Pancreatic Manifestations by Inactivating Vhl in Specific Pancreatic Cell Populations
por: Shen, H.-C. Jennifer, et al.
Publicado: (2009)

HIF2a inhibitors for the treatment of VHL disease
por: Metelo, Ana Martins, et al.
Publicado: (2015)

The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/Paraganglioma
por: Peng, Song, et al.
Publicado: (2020)

Loss of Von Hippel–Lindau (VHL) Tumor Suppressor Gene Function: VHL–HIF Pathway and Advances in Treatments for Metastatic Renal Cell Carcinoma (RCC)
por: Kim, Hyunho, et al.
Publicado: (2021)

Sporadic hemangioblastomas are characterized by cryptic VHL inactivation
por: Shankar, Ganesh M, et al.
Publicado: (2014)

Two sides to every story: the HIF-dependent and HIF-independent functions of pVHL
por: Li, Mingqing, et al.
Publicado: (2011)

An ID2-dependent mechanism for VHL inactivation in cancer
por: Lee, Sang Bae, et al.
Publicado: (2016)

Investigation of the role of VHL-HIF signaling in DNA repair and apoptosis in zebrafish
por: Kim, Hyejeong Rosemary, et al.
Publicado: (2020)

Integrated genomic analyses identify frequent gene fusion events and VHL inactivation in gastrointestinal stromal tumors
por: Kang, Guhyun, et al.
Publicado: (2015)

VHL inactivation without hypoxia is sufficient to achieve genome hypermethylation
por: Artemov, Artem V., et al.
Publicado: (2018)

Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene
por: Wykoff, C C, et al.
Publicado: (2004)

Extracellular Vesicles: An Emerging Mechanism Governing the Secretion and Biological Roles of Tenascin-C
por: Albacete-Albacete, Lucas, et al.
Publicado: (2021)

Inactivation of HIF‐prolyl 4‐hydroxylases 1, 2 and 3 in NG2‐expressing cells induces HIF2‐mediated neurovascular expansion independent of erythropoietin
por: Urrutia, Andrés A., et al.
Publicado: (2020)

CGC phenomenology at RHIC and the LHC
por: Albacete, Javier L.
Publicado: (2010)

Histone deacetylase inhibitor induced pVHL-independent degradation of HIF-1α and hierarchical quality control of pVHL via chaperone system
por: Ni, Jieming, et al.
Publicado: (2021)

HIF-2α downregulation in the absence of functional VHL is not sufficient for renal cell differentiation
por: Hughes, Michael D, et al.
Publicado: (2007)

Inhibition of HIF2α Is Sufficient to Suppress pVHL-Defective Tumor Growth
por: Kondo, Keiichi, et al.
Publicado: (2003)

Inhibition of HIF2α Protein Suppresses pVHL-Driven Tumor Growth
Publicado: (2003)

Oxygen-independent degradation of HIF-α via bioengineered VHL tumour suppressor complex
por: Sufan, Roxana I, et al.
Publicado: (2009)

Genomic copy number alterations in clear cell renal carcinoma: associations with case characteristics and mechanisms of VHL gene inactivation
por: Moore, L E, et al.
Publicado: (2012)

Endothelial cells by inactivation of VHL gene direct angiogenesis, not vasculogenesis via Twist1 accumulation associated with hemangioblastoma neovascularization
por: Wang, Ying, et al.
Publicado: (2017)

Von Hippel-Lindau (VHL) Inactivation in Sporadic Clear Cell Renal Cancer: Associations with Germline VHL Polymorphisms and Etiologic Risk Factors
por: Moore, Lee E., et al.
Publicado: (2011)

HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
por: Tarade, Daniel, et al.
Publicado: (2018)

Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α
por: Tarade, Daniel, et al.
Publicado: (2019)

Vhl deletion in renal epithelia causes HIF-1α-dependent, HIF-2α-independent angiogenesis and constitutive diuresis
por: Schönenberger, Désirée, et al.
Publicado: (2016)

Hypoxia Inactivates the VHL Tumor Suppressor through PIASy-Mediated SUMO Modification
por: Cai, Qiliang, et al.
Publicado: (2010)

VHL-1 inactivation and mitochondrial antioxidants rescue C. elegans dopaminergic neurodegeneration
por: Chen, Song, et al.
Publicado: (2019)

Seguridad en equipos informáticos
por: Giménez Albacete, José Francisco
Publicado: (2014)

Inactivation of the tumor suppressor gene von Hippel-Lindau (VHL) in granulocytes contributes to development of liver hemangiomas in a mouse model
por: Bader, Hannah L., et al.
Publicado: (2016)

Differential Contribution of N- and C-Terminal Regions of HIF1α and HIF2α to Their Target Gene Selectivity
por: Bouthelier, Antonio, et al.
Publicado: (2020)

Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye
por: Kurihara, Toshihide, et al.
Publicado: (2011)

Epigenetic expansion of VHL-HIF signal output drives multi-organ metastasis in renal cancer
por: Vanharanta, Sakari, et al.
Publicado: (2012)

Septin4 promotes cardiomyocytes apoptosis by enhancing the VHL-mediated degradation of HIF-1α
por: Wu, Shaojun, et al.
Publicado: (2021)

Comprehensive characterization of Alu‐mediated breakpoints in germline VHL gene deletions and rearrangements in patients from 71 VHL families
por: Vocke, Cathy D., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_out0cet7j0bm3th5o1bqb81qsp