Novel post-synthetic generation, isomeric resolution, and characterization of Fapy-dG within oligodeoxynucleotides: differential anomeric impacts on DNA duplex properties

Accumulation of damaged guanine nucleobases within genomic DNA, including the imidazole ring opened N(6)-(2-Deoxy-α,β-D-erythro-pentafuranosyl)-2,6-diamino-4-hydroxy-5-formylamidopyrimidine (Fapy-dG), is associated with progression of age-related diseases and cancer. To evaluate the impact of this m...

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Detalles Bibliográficos
Autores principales: Lukin, Mark, Minetti, Conceição A. S. A., Remeta, David P., Attaluri, Sivaprasad, Johnson, Francis, Breslauer, Kenneth J., de los Santos, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Synthetic Biology and Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141231/
https://www.ncbi.nlm.nih.gov/pubmed/21415012
http://dx.doi.org/10.1093/nar/gkr082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141231/
https://www.ncbi.nlm.nih.gov/pubmed/21415012
http://dx.doi.org/10.1093/nar/gkr082

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