Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters

Synthetic small duplex RNAs that are fully complementary to gene promoters can silence transcription in mammalian cells. microRNAs (miRNAs) are endogenous small regulatory RNAs that sequence specifically regulate gene expression. We have developed a computational method to identify potential miRNA t...

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Detalles Bibliográficos
Autores principales: Younger, Scott T., Corey, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141263/
https://www.ncbi.nlm.nih.gov/pubmed/21427083
http://dx.doi.org/10.1093/nar/gkr155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141263/
https://www.ncbi.nlm.nih.gov/pubmed/21427083
http://dx.doi.org/10.1093/nar/gkr155

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