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Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters
Synthetic small duplex RNAs that are fully complementary to gene promoters can silence transcription in mammalian cells. microRNAs (miRNAs) are endogenous small regulatory RNAs that sequence specifically regulate gene expression. We have developed a computational method to identify potential miRNA t...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141263/ https://www.ncbi.nlm.nih.gov/pubmed/21427083 http://dx.doi.org/10.1093/nar/gkr155 |