Inhibition of mutant huntingtin expression by RNA duplex targeting expanded CAG repeats

The specific silencing of the gene of interest is the major objective of RNA interference technology; therefore, unique sequences but not abundant sequence repeats are targeted by silencing reagents. Here, we describe the targeting of expanded CAG repeats that occur in transcripts derived from the m...

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Detalles Bibliográficos
Autores principales: Fiszer, Agnieszka, Mykowska, Agnieszka, Krzyzosiak, Wlodzimierz J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141264/
https://www.ncbi.nlm.nih.gov/pubmed/21427085
http://dx.doi.org/10.1093/nar/gkr156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141264/
https://www.ncbi.nlm.nih.gov/pubmed/21427085
http://dx.doi.org/10.1093/nar/gkr156

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