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Inhibition of mutant huntingtin expression by RNA duplex targeting expanded CAG repeats
The specific silencing of the gene of interest is the major objective of RNA interference technology; therefore, unique sequences but not abundant sequence repeats are targeted by silencing reagents. Here, we describe the targeting of expanded CAG repeats that occur in transcripts derived from the m...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141264/ https://www.ncbi.nlm.nih.gov/pubmed/21427085 http://dx.doi.org/10.1093/nar/gkr156 |