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Single-molecule analysis of genome rearrangements in cancer

Rearrangements of the genome can be detected by microarray methods and massively parallel sequencing, which identify copy-number alterations and breakpoint junctions, but these techniques are poorly suited to reconstructing the long-range organization of rearranged chromosomes, for example, to disti...

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Detalles Bibliográficos
Autores principales: Pole, Jessica C. M., McCaughan, Frank, Newman, Scott, Howarth, Karen D., Dear, Paul H., Edwards, Paul A. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141271/
https://www.ncbi.nlm.nih.gov/pubmed/21525129
http://dx.doi.org/10.1093/nar/gkr227