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Intrathecal lidocaine pretreatment attenuates immediate neuropathic pain by modulating Nav(1.3 )expression and decreasing spinal microglial activation
BACKGROUND: Intrathecal lidocaine reverses tactile allodynia after nerve injury, but whether neuropathic pain is attenuated by intrathecal lidocaine pretreatment is uncertain. METHODS: Sixty six adult male Sprague-Dawley rats were divided into three treatment groups: (1) sham (Group S), which underw...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141398/ https://www.ncbi.nlm.nih.gov/pubmed/21676267 http://dx.doi.org/10.1186/1471-2377-11-71 |