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Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells
BACKGROUND: Prolonged elevated levels of lipids have negative effects on beta-cell function and mass (lipotoxicity). To what extent exposure to high glucose concentration is important in the harmful effects of lipids (glucolipotoxicity) has been debated. METHODS: We addressed beta-cell lipotoxicity...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141549/ https://www.ncbi.nlm.nih.gov/pubmed/21745359 http://dx.doi.org/10.1186/1476-511X-10-115 |