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Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells

BACKGROUND: Prolonged elevated levels of lipids have negative effects on beta-cell function and mass (lipotoxicity). To what extent exposure to high glucose concentration is important in the harmful effects of lipids (glucolipotoxicity) has been debated. METHODS: We addressed beta-cell lipotoxicity...

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Detalles Bibliográficos
Autores principales: Sargsyan, Ernest, Bergsten, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141549/
https://www.ncbi.nlm.nih.gov/pubmed/21745359
http://dx.doi.org/10.1186/1476-511X-10-115

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