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Altered efficacy of AT1R-targeted treatment after spontaneous cancer cell-AT1R upregulation

BACKGROUND: Targeting of the renin angiotensin system (RAS) reduces tumour growth in experimental models of cancer. We aimed to establish if combined targeting of the 'classical' and 'alternative' arms of the RAS could result in synergistic inhibition of colorectal cancer (CRC) l...

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Detalles Bibliográficos
Autores principales: Ager, Eleanor I, Wen, Shu Wen, Chan, Joyna, Chong, Way W, Neo, Jaclyn H, Christophi, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141779/
https://www.ncbi.nlm.nih.gov/pubmed/21703011
http://dx.doi.org/10.1186/1471-2407-11-274