Cargando…

Formulation and pharmacokinetic evaluation of a paclitaxel nanosuspension for intravenous delivery

Paclitaxel is a diterpenoid isolated from Taxus brevifolia. It is effective for various cancers, especially ovarian and breast cancer. Due to its aqueous insolubility, it is administered dissolved in ethanol and Cremophor(®) EL (BASF, Ludwigshafen, Germany), which can cause serious allergic reaction...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yonglu, Li, Xueming, Wang, Liyao, Xu, Yuanlong, Cheng, Xiaodan, Wei, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2011
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141875/ https://www.ncbi.nlm.nih.gov/pubmed/21796250 http://dx.doi.org/10.2147/IJN.S21097

Ejemplares similares

Study on Formulation, in vivo Exposure, and Passive Targeting of Intravenous Itraconazole Nanosuspensions
por: Yuan, Qi, et al.
Publicado: (2019)

Itraconazole nanosuspension for oral delivery: Formulation, characterization and in vitro comparison with marketed formulation
por: Nakarani, M., et al.
Publicado: (2010)

Formulation and evaluation of docetaxel nanosuspensions: In-vitro evaluation and cytotoxicity
por: Ibrahim, Mohamed A., et al.
Publicado: (2019)

Pharmacokinetic evaluation of a 1,3-dicyclohexylurea nanosuspension formulation to support early efficacy assessment
por: Wahlstrom, Jan L, et al.
Publicado: (2007)

Preparation, characterization and pharmacokinetics of cyadox nanosuspension
por: Sattar, Adeel, et al.
Publicado: (2017)

Nanosuspension delivery of paclitaxel to xenograft mice can alter drug disposition and anti-tumor activity
por: Chiang, Po-Chang, et al.
Publicado: (2014)

Formulation Strategies of Nanosuspensions for Various Administration Routes
por: Pınar, Sıla Gülbağ, et al.
Publicado: (2023)

Amorphous Nanosuspensions Aggregated from Paclitaxel–Hemoglobulin Complexes with Enhanced Cytotoxicity
por: Qin, Chao, et al.
Publicado: (2018)

Sustained delivery of a camptothecin prodrug – CZ48 by nanosuspensions with improved pharmacokinetics and enhanced anticancer activity
por: Dong, Dong, et al.
Publicado: (2019)

Pharmacokinetics and Anti-Diabetic Studies of Gliclazide Nanosuspension
por: Sampathi, Sunitha, et al.
Publicado: (2022)

Preparation and Pharmacokinetic Characterization of an Anti-Virulence Compound Nanosuspensions
por: Wang, Nan, et al.
Publicado: (2021)

Evaluation of Aerosol Delivery of Nanosuspension for Pre-clinical Pulmonary Drug Delivery
por: Chiang, Po-Chang, et al.
Publicado: (2009)

Investigation of utilization of nanosuspension formulation to enhance exposure of 1,3-dicyclohexylurea in rats: Preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery
por: Chiang, Po-Chang, et al.
Publicado: (2011)

Cyclosporine A-Nanosuspension: Formulation, Characterization and In Vivo Comparison with a Marketed Formulation
por: Nakarani, Mahendra, et al.
Publicado: (2010)

Lyoprotectant Formulation and Optimization of the J-Aggregates Astaxanthin/BSA/Chitosan Nanosuspension
por: Zhao, Yingyuan, et al.
Publicado: (2023)

Emerging role of nanosuspensions in drug delivery systems
por: Jacob, Shery, et al.
Publicado: (2020)

Nose to brain delivery of Efavirenz nanosuspension for effective neuro AIDS therapy: in-vitro, in-vivo and pharmacokinetic assessment
por: Kakad, Smita, et al.
Publicado: (2021)

Formulation and Process Optimization of Rauvolfia serpentina Nanosuspension by HPMC and In Vitro Evaluation of ACE Inhibitory Potential
por: Touqeer, Syeeda Iram, et al.
Publicado: (2022)

Nanosuspension Technology: Recent Patents on Drug Delivery and their Characterizations
por: Goel, Surya, et al.
Publicado: (2019)

Deferasirox Nanosuspension Loaded Dissolving Microneedles for Intradermal Delivery
por: Faizi, Hafsa Shahid, et al.
Publicado: (2022)

Enhancement of oral bioavailability of quercetin by metabolic inhibitory nanosuspensions compared to conventional nanosuspensions
por: Li, Haowen, et al.
Publicado: (2021)

Influence of Stabilizer on the Development of Luteolin Nanosuspension for Cutaneous Delivery: An In Vitro and In Vivo Evaluation
por: Elmowafy, Mohammed, et al.
Publicado: (2021)

Enhanced Antihypertensive Activity of Candesartan Cilexetil Nanosuspension: Formulation, Characterization and Pharmacodynamic Study
por: Detroja, Chetan, et al.
Publicado: (2011)

Evaluating the Suitability of Using Rat Models for Preclinical Efficacy and Side Effects with Inhaled Corticosteroids Nanosuspension Formulations
por: Chiang, Po-Chang, et al.
Publicado: (2010)

Design, formulation and evaluation of novel dissolving microarray patches containing a long-acting rilpivirine nanosuspension
por: Mc Crudden, Maelíosa T.C., et al.
Publicado: (2018)

Optimization of Extended-Release ZL-004 Nanosuspensions for In Vivo Pharmacokinetic Study to Enhance Low Solubility and Compliance
por: Guo, Chengyue, et al.
Publicado: (2018)

Phase I and Pharmacokinetic Study of Paclitaxel by 24‐Hour Intravenous Infusion
por: Tamura, Tomohide, et al.
Publicado: (1994)

Nanosuspension-Based Dissolving Microneedle Arrays for Intradermal Delivery of Curcumin
por: Abdelghany, Sharif, et al.
Publicado: (2019)

Nose-to-Brain Delivery by Nanosuspensions-Based in situ Gel for Breviscapine
por: Chen, Yingchong, et al.
Publicado: (2020)

Formulation and Development of Oral Fast-Dissolving Films Loaded with Nanosuspension to Augment Paroxetine Bioavailability: In Vitro Characterization, Ex Vivo Permeation, and Pharmacokinetic Evaluation in Healthy Human Volunteers
por: Elshafeey, Ahmed Hassen, et al.
Publicado: (2021)

Investigation of formulation variables affecting the properties of lamotrigine nanosuspension using fractional factorial design
por: B., Mishra, et al.
Publicado: (2010)

The Impact of Process and Formulation Parameters on the Fabrication of Efavirenz Nanosuspension to Improve Drug Solubility and Dissolution
por: Rashed, Mahtab, et al.
Publicado: (2022)

Ceramide lipid-based nanosuspension for enhanced delivery of docetaxel with synergistic antitumor efficiency
por: Wang, Tianqi, et al.
Publicado: (2017)

Combination of Dissolving Microneedles with Nanosuspension and Co-Grinding for Transdermal Delivery of Ketoprofen
por: Ramadon, Delly, et al.
Publicado: (2023)

Nanosuspension-Based Dissolvable Microneedle Arrays to Enhance Diclofenac Skin Delivery
por: Casula, Luca, et al.
Publicado: (2023)

Solubility Determination of c-Met Inhibitor in Solvent Mixtures and Mathematical Modeling to Develop Nanosuspension Formulation
por: Ravi, Maharjan, et al.
Publicado: (2021)

Development of Nanosuspension Formulations Compatible with Inkjet Printing for the Convenient and Precise Dispensing of Poorly Soluble Drugs
por: Leung, Dennis H.
Publicado: (2022)

Intravenous delivery of a liposomal formulation of voriconazole improves drug pharmacokinetics, tissue distribution, and enhances antifungal activity
por: Veloso, Danillo F. M. C., et al.
Publicado: (2018)

Synthesis and characterization of tumor-targeted copolymer nanocarrier modified by transferrin
por: Liu, Ran, et al.
Publicado: (2015)

Combined Delivery of Paclitaxel and Tanespimycin via Micellar Nanocarriers: Pharmacokinetics, Efficacy and Metabolomic Analysis
por: Katragadda, Usha, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_svq895rsd413ousbp2uurqmmub