Heterozygous Inactivation of the Na/Ca Exchanger Increases Glucose-Induced Insulin Release, β-Cell Proliferation, and Mass

OBJECTIVE: We have previously shown that overexpression of the Na-Ca exchanger (NCX1), a protein responsible for Ca(2+) extrusion from cells, increases β-cell programmed cell death (apoptosis) and reduces β-cell proliferation. To further characterize the role of NCX1 in β-cells under in vivo conditi...

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Detalles Bibliográficos
Autores principales: Nguidjoe, Evrard, Sokolow, Sophie, Bigabwa, Serge, Pachera, Nathalie, D'Amico, Eva, Allagnat, Florent, Vanderwinden, Jean-Marie, Sener, Abdullah, Manto, Mario, Depreter, Marianne, Mast, Jan, Joanny, Geraldine, Montanya, Eduard, Rahier, Jacques, Cardozo, Alessandra K., Eizirik, Décio L., Schurmans, Stéphane, Herchuelz, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142081/
https://www.ncbi.nlm.nih.gov/pubmed/21659499
http://dx.doi.org/10.2337/db10-0924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142081/
https://www.ncbi.nlm.nih.gov/pubmed/21659499
http://dx.doi.org/10.2337/db10-0924

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