Epigenetic Silencing of Nucleolar rRNA Genes in Alzheimer's Disease

BACKGROUND: Ribosomal deficits are documented in mild cognitive impairment (MCI), which often represents an early stage Alzheimer's disease (AD), as well as in advanced AD. The nucleolar rRNA genes (rDNA), transcription of which is critical for ribosomal biogenesis, are regulated by epigenetic...

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Detalles Bibliográficos
Autores principales: Pietrzak, Maciej, Rempala, Grzegorz, Nelson, Peter T., Zheng, Jing-Juan, Hetman, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142181/
https://www.ncbi.nlm.nih.gov/pubmed/21799908
http://dx.doi.org/10.1371/journal.pone.0022585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142181/
https://www.ncbi.nlm.nih.gov/pubmed/21799908
http://dx.doi.org/10.1371/journal.pone.0022585

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