Cargando…

Epigenetic Silencing of Nucleolar rRNA Genes in Alzheimer's Disease

BACKGROUND: Ribosomal deficits are documented in mild cognitive impairment (MCI), which often represents an early stage Alzheimer's disease (AD), as well as in advanced AD. The nucleolar rRNA genes (rDNA), transcription of which is critical for ribosomal biogenesis, are regulated by epigenetic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pietrzak, Maciej, Rempala, Grzegorz, Nelson, Peter T., Zheng, Jing-Juan, Hetman, Michal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142181/ https://www.ncbi.nlm.nih.gov/pubmed/21799908 http://dx.doi.org/10.1371/journal.pone.0022585

Ejemplares similares

The nucleolar origin of rRNA
por: Wells, William A.
Publicado: (2005)

Replication protein A associates with nucleolar R loops and regulates rRNA transcription and nucleolar morphology
por: Feng, Shuang, et al.
Publicado: (2021)

Small nucleolar RNAs controlling rRNA processing in Trypanosoma brucei
por: Chikne, Vaibhav, et al.
Publicado: (2019)

rRNA transcription is integral to phase separation and maintenance of nucleolar structure
por: Dash, Soma, et al.
Publicado: (2023)

A small nucleolar RNA functions in rRNA processing in Caenorhabditis elegans
por: Hokii, Yusuke, et al.
Publicado: (2010)

A Functional Interface at the rDNA Connects rRNA Synthesis, Pre-rRNA Processing and Nucleolar Surveillance in Budding Yeast
por: Leporé, Nathalie, et al.
Publicado: (2011)

A high-throughput assay for directly monitoring nucleolar rRNA biogenesis
por: Bryant, Carson J., et al.
Publicado: (2022)

Human nucleolar protein 7 (NOL7) is required for early pre-rRNA accumulation and pre-18S rRNA processing
por: McCool, Mason A., et al.
Publicado: (2023)

The nucleolar protein NOL12 is required for processing of large ribosomal subunit rRNA precursors in Arabidopsis
por: Zakrzewska-Placzek, Monika, et al.
Publicado: (2023)

The BRCT domain of mammalian Pes1 is crucial for nucleolar localization and rRNA processing
por: Hölzel, Michael, et al.
Publicado: (2007)

Effects of Hydrogen Peroxide Stress on the Nucleolar Redox Environment and Pre-rRNA Maturation
por: Sapio, Russell T., et al.
Publicado: (2021)

Nucleolar sub-compartments in motion during rRNA synthesis inhibition: Contraction of nucleolar condensed chromatin and gathering of fibrillar centers are concomitant
por: Tchelidze, Pavel, et al.
Publicado: (2017)

The nucleolar protein SAHY1 is involved in pre-rRNA processing and normal plant growth
por: Hsu, Pei-jung, et al.
Publicado: (2020)

The Human Nucleolar Protein FTSJ3 Associates with NIP7 and Functions in Pre-rRNA Processing
por: Morello, Luis G., et al.
Publicado: (2011)

ING1 regulates rRNA levels by altering nucleolar chromatin structure and mTOR localization
por: Rajarajacholan, Uma Karthika, et al.
Publicado: (2017)

Local inhibition of rRNA transcription without nucleolar segregation after targeted ion irradiation of the nucleolus
por: Siebenwirth, Christian, et al.
Publicado: (2019)

Repression of rRNA gene transcription by endothelial SPEN deficiency normalizes tumor vasculature via nucleolar stress
por: Yang, Zi-Yan, et al.
Publicado: (2023)

GRIM-1, a Novel Growth Suppressor, Inhibits rRNA Maturation by Suppressing Small Nucleolar RNAs
por: Nallar, Shreeram C., et al.
Publicado: (2011)

SGNP: An Essential Stress Granule/Nucleolar Protein Potentially Involved in 5.8s rRNA Processing/Transport
por: Zhu, Chun-Hong, et al.
Publicado: (2008)

Early rRNA processing is a stress-dependent regulatory event whose inhibition maintains nucleolar integrity
por: Szaflarski, Witold, et al.
Publicado: (2021)

Human nucleolar protein SURF6/RRP14 participates in early steps of pre-rRNA processing
por: Moraleva, Anastasiia, et al.
Publicado: (2023)

Nucleolar Assembly of the Rrna Processing Machinery in Living Cells
por: Savino, Tulia Maria, et al.
Publicado: (2001)

Locus-Specific Ribosomal RNA Gene Silencing in Nucleolar Dominance
por: Lewis, Michelle S., et al.
Publicado: (2007)

Nucleolar DEAD-Box RNA Helicase TOGR1 Regulates Thermotolerant Growth as a Pre-rRNA Chaperone in Rice
por: Wang, Dong, et al.
Publicado: (2016)

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing
por: Chen, Yingxiao, et al.
Publicado: (2023)

Nucleolar PARP-1 Expression Is Decreased in Alzheimer's Disease: Consequences for Epigenetic Regulation of rDNA and Cognition
por: Zeng, Jianying, et al.
Publicado: (2016)

rRNA biogenesis regulates mouse 2C-like state by 3D structure reorganization of peri-nucleolar heterochromatin
por: Yu, Hua, et al.
Publicado: (2021)

High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation
por: Sokka, Miiko, et al.
Publicado: (2015)

Nucleolar TRF2 attenuated nucleolus stress-induced HCC cell-cycle arrest by altering rRNA synthesis
por: Yuan, Fuwen, et al.
Publicado: (2018)

BCCIP is required for nucleolar recruitment of eIF6 and 12S pre-rRNA production during 60S ribosome biogenesis
por: Ye, Caiyong, et al.
Publicado: (2020)

Beyond rRNA: nucleolar transcription generates a complex network of RNAs with multiple roles in maintaining cellular homeostasis
por: Feng, Shuang, et al.
Publicado: (2022)

The N-terminus of Stag1 is required to repress the 2C program by maintaining rRNA expression and nucleolar integrity
por: Pezic, Dubravka, et al.
Publicado: (2023)

Nucleolar Targeting by Platinum: p53-Independent Apoptosis Follows rRNA Inhibition, Cell-Cycle Arrest, and DNA Compaction
por: Peterson, Erica J., et al.
Publicado: (2014)

Association of Yeast RNA Polymerase I with a Nucleolar Substructure Active in Rrna Synthesis and Processing
por: Fath, Stephan, et al.
Publicado: (2000)

Dichotomous Impact of Myc on rRNA Gene Activation and Silencing in B Cell Lymphomagenesis
por: Joshi, Gaurav, et al.
Publicado: (2020)

Beyond rRNA and snRNA: tRNA as a 2′-O-methylation target for nucleolar and Cajal body box C/D RNPs
por: Nostramo, Regina T., et al.
Publicado: (2019)

NICOTIANAMINE SYNTHASE activity affects nucleolar iron accumulation and impacts rDNA silencing and RNA methylation in Arabidopsis
por: Montacié, Charlotte, et al.
Publicado: (2023)

A Genetic Cascade of let-7-ncl-1-fib-1 Modulates Nucleolar Size and rRNA Pool in Caenorhabditis elegans
por: Yi, Yung-Hsiang, et al.
Publicado: (2015)

High dimensional model representation of log-likelihood ratio: binary classification with expression data
por: Foroughi pour, Ali, et al.
Publicado: (2020)

An Intergenic Non-Coding rRNA Correlated with Expression of the rRNA and Frequency of an rRNA Single Nucleotide Polymorphism in Lung Cancer Cells
por: Shiao, Yih-Horng, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_4g4caap2jdi1na50ojdv8ed3aj