SAMHD1: a new insight into HIV-1 restriction in myeloid cells

Human myeloid-lineage cells are refractory to HIV-1 infection. The Vpx proteins from HIV-2 and sooty mangabey SIV render these cells permissive to HIV-1 infection through proteasomal degradation of a putative restriction factor. Two recent studies discovered the cellular protein SAMHD1 to be this re...

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Detalles Bibliográficos
Autores principales: St Gelais, Corine, Wu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Viewpoints
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142215/
https://www.ncbi.nlm.nih.gov/pubmed/21740548
http://dx.doi.org/10.1186/1742-4690-8-55

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142215/
https://www.ncbi.nlm.nih.gov/pubmed/21740548
http://dx.doi.org/10.1186/1742-4690-8-55

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