RasGAP-Derived Fragment N Increases the Resistance of Beta Cells towards Apoptosis in NOD Mice and Delays the Progression from Mild to Overt Diabetes

The caspase-3-generated RasGAP N-terminal fragment (fragment N) inhibits apoptosis in a Ras-PI3K-Akt-dependent manner. Fragment N protects various cell types, including insulin-secreting cells, against different types of stresses. Whether fragment N exerts a protective role during the development of...

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Detalles Bibliográficos
Autores principales: Bulat, Natasa, Jaccard, Evrim, Peltzer, Nieves, Khalil, Hadi, Yang, Jiang-Yan, Dubuis, Gilles, Widmann, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143162/
https://www.ncbi.nlm.nih.gov/pubmed/21799917
http://dx.doi.org/10.1371/journal.pone.0022609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143162/
https://www.ncbi.nlm.nih.gov/pubmed/21799917
http://dx.doi.org/10.1371/journal.pone.0022609

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