Cargando…

Acidic Environment Leads to ROS-Induced MAPK Signaling in Cancer Cells

Tumor micromilieu often shows pronounced acidosis forcing cells to adapt their phenotype towards enhanced tumorigenesis induced by altered cellular signalling and transcriptional regulation. In the presents study mechanisms and potential consequences of the crosstalk between extra- and intracellular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Riemann, Anne, Schneider, Bettina, Ihling, Angelika, Nowak, Martin, Sauvant, Christoph, Thews, Oliver, Gekle, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144229/ https://www.ncbi.nlm.nih.gov/pubmed/21818325 http://dx.doi.org/10.1371/journal.pone.0022445

Ejemplares similares

Impact of the acidic environment on gene expression and functional parameters of tumors in vitro and in vivo
por: Rauschner, Mandy, et al.
Publicado: (2021)

PAH clearance after renal ischemia and reperfusion is a function of impaired expression of basolateral Oat1 and Oat3
por: Bischoff, Ariane, et al.
Publicado: (2014)

Tumor Acidosis and Hypoxia Differently Modulate the Inflammatory Program: Measurements In Vitro and In Vivo
por: Riemann, Anne, et al.
Publicado: (2017)

Extracellular Acidosis Modulates the Expression of Epithelial-Mesenchymal Transition (EMT) Markers and Adhesion of Epithelial and Tumor Cells
por: Riemann, Anne, et al.
Publicado: (2019)

The risk of indoor sports and culture events for the transmission of COVID-19
por: Moritz, Stefan, et al.
Publicado: (2021)

ROS mediated MAPK signaling in abiotic and biotic stress- striking similarities and differences
por: Jalmi, Siddhi K., et al.
Publicado: (2015)

Role of acidosis-sensitive microRNAs in gene expression and functional parameters of tumors in vitro and in vivo
por: Rauschner, Mandy, et al.
Publicado: (2021)

Perfluorooctanoic acid-induced cell death via the dual roles of ROS-MAPK/ERK signaling in ameloblast-lineage cells
por: Fujiwara, Natsumi, et al.
Publicado: (2023)

Sunitinib induced hepatotoxicity in L02 cells via ROS-MAPKs signaling pathway
por: Tang, Ting-Li, et al.
Publicado: (2022)

Inhibition of Carbonic Anhydrase IX by Ureidosulfonamide Inhibitor U104 Reduces Prostate Cancer Cell Growth, But Does Not Modulate Daunorubicin or Cisplatin Cytotoxicity
por: Riemann, Anne, et al.
Publicado: (2018)

Extracellular ATP activates MAPK and ROS signaling during injury response in the fungus Trichoderma atroviride
por: Medina-Castellanos, Elizabeth, et al.
Publicado: (2014)

Costunolide Induces Autophagy and Apoptosis by Activating ROS/MAPK Signaling Pathways in Renal Cell Carcinoma
por: Fu, Dian, et al.
Publicado: (2020)

Non-Esterified Fatty Acid Induces ER Stress-Mediated Apoptosis via ROS/MAPK Signaling Pathway in Bovine Mammary Epithelial Cells
por: Yan, Yexiao, et al.
Publicado: (2022)

Indoxyl sulfate reduces I(to,f) by activating ROS/MAPK and NF-κB signaling pathways
por: Yang, Jing, et al.
Publicado: (2022)

[6]-Gingerol induces Caspase-Dependent Apoptosis in Bladder Cancer cells via MAPK and ROS Signaling
por: Choi, Na Ri, et al.
Publicado: (2022)

ROS generation and autophagosome accumulation contribute to the DMAMCL-induced inhibition of glioma cell proliferation by regulating the ROS/MAPK signaling pathway and suppressing the Akt/mTOR signaling pathway
por: Wang, Yanjun, et al.
Publicado: (2019)

Increased tolerance to salt stress in OPDA-deficient rice ALLENE OXIDE CYCLASE mutants is linked to an increased ROS-scavenging activity
por: Hazman, Mohamed, et al.
Publicado: (2015)

Protective Effects of Green Tea Polyphenol Against Renal Injury Through ROS-Mediated JNK-MAPK Pathway in Lead Exposed Rats
por: Wang, Haidong, et al.
Publicado: (2016)

ROS and ROS-Mediated Cellular Signaling
por: Zhang, Jixiang, et al.
Publicado: (2016)

ROS Detoxification and Proinflammatory Cytokines Are Linked by p38 MAPK Signaling in a Model of Mature Astrocyte Activation
por: Nahirnyj, Adrian, et al.
Publicado: (2013)

Inhibition of p38 MAPK Signaling Augments Skin Tumorigenesis via NOX2 Driven ROS Generation
por: Liu, Liang, et al.
Publicado: (2014)

SYKT Alleviates Doxorubicin-Induced Cardiotoxicity via Modulating ROS-Mediated p53 and MAPK Signal Pathways
por: Chen, Ting, et al.
Publicado: (2018)

Zeaxanthin Induces Apoptosis via ROS-Regulated MAPK and AKT Signaling Pathway in Human Gastric Cancer Cells
por: Sheng, Ya-Nan, et al.
Publicado: (2020)

Rosiglitazone Affects Nitric Oxide Synthases and Improves Renal Outcome in a Rat Model of Severe Ischemia/Reperfusion Injury
por: Betz, Boris, et al.
Publicado: (2012)

NEFA‐induced ROS impaired insulin signalling through the JNK and p38MAPK pathways in non‐alcoholic steatohepatitis
por: Gao, Wenwen, et al.
Publicado: (2018)

Correction: Inhibition of p38 MAPK Signaling Augments Skin Tumorigenesis via NOX2 Driven ROS Generation
por: Liu, Liang, et al.
Publicado: (2017)

Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo
por: Fan, Jiangjiang, et al.
Publicado: (2020)

Phycocyanin inhibits Helicobacter pylori-induced hyper-proliferation in AGS cells via activation of the ROS/MAPK signaling pathway
por: Bi, Yakun, et al.
Publicado: (2022)

Acacetin resists UVA photoaging by mediating the SIRT3/ROS/MAPKs pathway
por: Mu, Jing, et al.
Publicado: (2022)

Aprepitant inhibits the development and metastasis of gallbladder cancer via ROS and MAPK activation
por: Cao, Xueyan, et al.
Publicado: (2023)

Hyperbaric oxygenation and glucose/amino acids substitution in human severe placental insufficiency
por: Tchirikov, Michael, et al.
Publicado: (2018)

Alternol, a natural compound, exerts an anti‐tumour effect on osteosarcoma by modulating of STAT3 and ROS/MAPK signalling pathways
por: Zuo, Dongqing, et al.
Publicado: (2016)

Copper Chaperone for Superoxide Dismutase Promotes Breast Cancer Cell Proliferation and Migration via ROS-Mediated MAPK/ERK Signaling
por: Li, Yanping, et al.
Publicado: (2019)

GhCIPK6a increases salt tolerance in transgenic upland cotton by involving in ROS scavenging and MAPK signaling pathways
por: Su, Ying, et al.
Publicado: (2020)

Luteolin Prevents UVB-Induced Skin Photoaging Damage by Modulating SIRT3/ROS/MAPK Signaling: An in vitro and in vivo Studies
por: Mu, Jing, et al.
Publicado: (2021)

Hispidin inhibits LPS-induced nitric oxide production in BV-2 microglial cells via ROS-dependent MAPK signaling
por: Jin, Mei-Hua, et al.
Publicado: (2021)

Semilicoisoflavone B Induces Apoptosis of Oral Cancer Cells by Inducing ROS Production and Downregulating MAPK and Ras/Raf/MEK Signaling
por: Hsieh, Ming-Ju, et al.
Publicado: (2023)

Maternal inflammation activated ROS-p38 MAPK predisposes offspring to heart damages caused by isoproterenol via augmenting ROS generation
por: Zhang, Qi, et al.
Publicado: (2016)

Induction of MAPK- and ROS-dependent autophagy and apoptosis in gastric carcinoma by combination of romidepsin and bortezomib
por: Hui, Kwai Fung, et al.
Publicado: (2015)

CHAC2 promotes lung adenocarcinoma by regulating ROS-mediated MAPK pathway activation
por: Peng, Weilin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rfkeond8tf58qqo4urrklpj07k