A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization

A deletion mutation called fro (fragilitas ossium) in the murine Smpd3 (sphingomyelin phosphodiesterase 3) gene leads to a severe skeletal dysplasia. Smpd3 encodes a neutral sphingomyelinase (nSMase2), which cleaves sphingomyelin to generate bioactive lipid metabolites. We examined endochondral ossi...

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Detalles Bibliográficos
Autores principales: Khavandgar, Zohreh, Poirier, Christophe, Clarke, Christopher J., Li, Jingjing, Wang, Nicholas, McKee, Marc D., Hannun, Yusuf A., Murshed, Monzur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144407/
https://www.ncbi.nlm.nih.gov/pubmed/21788370
http://dx.doi.org/10.1083/jcb.201102051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144407/
https://www.ncbi.nlm.nih.gov/pubmed/21788370
http://dx.doi.org/10.1083/jcb.201102051

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