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Neuroligins/LRRTMs prevent activity- and Ca(2+)/calmodulin-dependent synapse elimination in cultured neurons

Neuroligins (NLs) and leucine-rich repeat transmembrane proteins (LRRTMs) are postsynaptic cell adhesion molecules that bind to presynaptic neurexins. In this paper, we show that short hairpin ribonucleic acid–mediated knockdowns (KDs) of LRRTM1, LRRTM2, and/or NL-3, alone or together as double or t...

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Detalles Bibliográficos
Autores principales: Ko, Jaewon, Soler-Llavina, Gilberto J., Fuccillo, Marc V., Malenka, Robert C., Südhof, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144410/
https://www.ncbi.nlm.nih.gov/pubmed/21788371
http://dx.doi.org/10.1083/jcb.201101072