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Toward a Surrogate Marker of Malaria Exposure: Modeling Longitudinal Antibody Measurements under Outbreak Conditions

BACKGROUND: Biomarkers of exposure to Plasmodium falciparum would be a useful tool for the assessment of malaria burden and analysis of intervention and epidemiological studies. Antibodies to pre-erythrocytic antigens represent potential surrogates of exposure. METHODS AND FINDINGS: In an outbreak c...

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Autores principales: Campo, Joseph J., Whitman, Timothy J., Freilich, Daniel, Burgess, Timothy H., Martin, Gregory J., Doolan, Denise L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144875/
https://www.ncbi.nlm.nih.gov/pubmed/21818270
http://dx.doi.org/10.1371/journal.pone.0021826
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author Campo, Joseph J.
Whitman, Timothy J.
Freilich, Daniel
Burgess, Timothy H.
Martin, Gregory J.
Doolan, Denise L.
author_facet Campo, Joseph J.
Whitman, Timothy J.
Freilich, Daniel
Burgess, Timothy H.
Martin, Gregory J.
Doolan, Denise L.
author_sort Campo, Joseph J.
collection PubMed
description BACKGROUND: Biomarkers of exposure to Plasmodium falciparum would be a useful tool for the assessment of malaria burden and analysis of intervention and epidemiological studies. Antibodies to pre-erythrocytic antigens represent potential surrogates of exposure. METHODS AND FINDINGS: In an outbreak cohort of U.S. Marines deployed to Liberia, we modeled pre- and post-deployment IgG against P. falciparum sporozoites by immunofluorescence antibody test, and both IgG and IgM against the P. falciparum circumsporozoite protein by enzyme-linked immunosorbant assay. Modeling seroconversion thresholds by a fixed ratio, linear regression or nonlinear regression produced sensitivity for identification of exposed U.S. Marines between 58–70% and specificities between 87–97%, compared with malaria-naïve U.S. volunteers. Exposure was predicted in 30–45% of the cohort. CONCLUSION: Each of the three models tested has merits in different studies, but further development and validation in endemic populations is required. Overall, these models provide support for an antibody-based surrogate marker of exposure to malaria.
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spelling pubmed-31448752011-08-04 Toward a Surrogate Marker of Malaria Exposure: Modeling Longitudinal Antibody Measurements under Outbreak Conditions Campo, Joseph J. Whitman, Timothy J. Freilich, Daniel Burgess, Timothy H. Martin, Gregory J. Doolan, Denise L. PLoS One Research Article BACKGROUND: Biomarkers of exposure to Plasmodium falciparum would be a useful tool for the assessment of malaria burden and analysis of intervention and epidemiological studies. Antibodies to pre-erythrocytic antigens represent potential surrogates of exposure. METHODS AND FINDINGS: In an outbreak cohort of U.S. Marines deployed to Liberia, we modeled pre- and post-deployment IgG against P. falciparum sporozoites by immunofluorescence antibody test, and both IgG and IgM against the P. falciparum circumsporozoite protein by enzyme-linked immunosorbant assay. Modeling seroconversion thresholds by a fixed ratio, linear regression or nonlinear regression produced sensitivity for identification of exposed U.S. Marines between 58–70% and specificities between 87–97%, compared with malaria-naïve U.S. volunteers. Exposure was predicted in 30–45% of the cohort. CONCLUSION: Each of the three models tested has merits in different studies, but further development and validation in endemic populations is required. Overall, these models provide support for an antibody-based surrogate marker of exposure to malaria. Public Library of Science 2011-07-27 /pmc/articles/PMC3144875/ /pubmed/21818270 http://dx.doi.org/10.1371/journal.pone.0021826 Text en This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Campo, Joseph J.
Whitman, Timothy J.
Freilich, Daniel
Burgess, Timothy H.
Martin, Gregory J.
Doolan, Denise L.
Toward a Surrogate Marker of Malaria Exposure: Modeling Longitudinal Antibody Measurements under Outbreak Conditions
title Toward a Surrogate Marker of Malaria Exposure: Modeling Longitudinal Antibody Measurements under Outbreak Conditions
title_full Toward a Surrogate Marker of Malaria Exposure: Modeling Longitudinal Antibody Measurements under Outbreak Conditions
title_fullStr Toward a Surrogate Marker of Malaria Exposure: Modeling Longitudinal Antibody Measurements under Outbreak Conditions
title_full_unstemmed Toward a Surrogate Marker of Malaria Exposure: Modeling Longitudinal Antibody Measurements under Outbreak Conditions
title_short Toward a Surrogate Marker of Malaria Exposure: Modeling Longitudinal Antibody Measurements under Outbreak Conditions
title_sort toward a surrogate marker of malaria exposure: modeling longitudinal antibody measurements under outbreak conditions
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144875/
https://www.ncbi.nlm.nih.gov/pubmed/21818270
http://dx.doi.org/10.1371/journal.pone.0021826
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