Predicting Inactive Conformations of Protein Kinases Using Active Structures: Conformational Selection of Type-II Inhibitors

Protein kinases have been found to possess two characteristic conformations in their activation-loops: the active DFG-in conformation and the inactive DFG-out conformation. Recently, it has been very interesting to develop type-II inhibitors which target the DFG-out conformation and are more specifi...

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Detalles Bibliográficos
Autores principales: Xu, Min, Yu, Lu, Wan, Bo, Yu, Long, Huang, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144914/
https://www.ncbi.nlm.nih.gov/pubmed/21818358
http://dx.doi.org/10.1371/journal.pone.0022644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144914/
https://www.ncbi.nlm.nih.gov/pubmed/21818358
http://dx.doi.org/10.1371/journal.pone.0022644

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