Therapeutic Rescue of Misfolded Mutants: Validation of Primary High Throughput Screens for Identification of Pharmacoperone Drugs

BACKGROUND: Functional rescue of misfolded mutant receptors by small non-peptide molecules has been demonstrated. These small, target-specific molecules (pharmacological chaperones or “pharmacoperones”) serve as molecular templates, promote correct folding and allow otherwise misfolded mutants to pa...

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Detalles Bibliográficos
Autores principales: Janovick, Jo Ann, Park, Byung S., Conn, P. Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144936/
https://www.ncbi.nlm.nih.gov/pubmed/21818389
http://dx.doi.org/10.1371/journal.pone.0022784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144936/
https://www.ncbi.nlm.nih.gov/pubmed/21818389
http://dx.doi.org/10.1371/journal.pone.0022784

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