Contrasting human X-linked and autosomal variation in population-scale whole genome sequencing

The ratio of genetic diversity on chromosome X to that on the autosomes is sensitive to both natural selection and demography. Based on whole-genome sequences of 69 females, we report that while this ratio increases with genetic distance from genes across populations, it is lower in Europeans than i...

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Autores principales: Gottipati, Srikanth, Arbiza, Leonardo, Siepel, Adam, Clark, Andrew G., Keinan, Alon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145052/
https://www.ncbi.nlm.nih.gov/pubmed/21775991
http://dx.doi.org/10.1038/ng.877
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author Gottipati, Srikanth
Arbiza, Leonardo
Siepel, Adam
Clark, Andrew G.
Keinan, Alon
author_facet Gottipati, Srikanth
Arbiza, Leonardo
Siepel, Adam
Clark, Andrew G.
Keinan, Alon
author_sort Gottipati, Srikanth
collection PubMed
description The ratio of genetic diversity on chromosome X to that on the autosomes is sensitive to both natural selection and demography. Based on whole-genome sequences of 69 females, we report that while this ratio increases with genetic distance from genes across populations, it is lower in Europeans than in West Africans independent of proximity to genes. This relative reduction is most parsimoniously explained by differences in demographic history without the need to invoke natural selection.
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spelling pubmed-31450522012-02-01 Contrasting human X-linked and autosomal variation in population-scale whole genome sequencing Gottipati, Srikanth Arbiza, Leonardo Siepel, Adam Clark, Andrew G. Keinan, Alon Nat Genet Article The ratio of genetic diversity on chromosome X to that on the autosomes is sensitive to both natural selection and demography. Based on whole-genome sequences of 69 females, we report that while this ratio increases with genetic distance from genes across populations, it is lower in Europeans than in West Africans independent of proximity to genes. This relative reduction is most parsimoniously explained by differences in demographic history without the need to invoke natural selection. 2011-07-24 /pmc/articles/PMC3145052/ /pubmed/21775991 http://dx.doi.org/10.1038/ng.877 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Gottipati, Srikanth
Arbiza, Leonardo
Siepel, Adam
Clark, Andrew G.
Keinan, Alon
Contrasting human X-linked and autosomal variation in population-scale whole genome sequencing
title Contrasting human X-linked and autosomal variation in population-scale whole genome sequencing
title_full Contrasting human X-linked and autosomal variation in population-scale whole genome sequencing
title_fullStr Contrasting human X-linked and autosomal variation in population-scale whole genome sequencing
title_full_unstemmed Contrasting human X-linked and autosomal variation in population-scale whole genome sequencing
title_short Contrasting human X-linked and autosomal variation in population-scale whole genome sequencing
title_sort contrasting human x-linked and autosomal variation in population-scale whole genome sequencing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145052/
https://www.ncbi.nlm.nih.gov/pubmed/21775991
http://dx.doi.org/10.1038/ng.877
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