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Genetic Anticipation Is Associated with Telomere Shortening in Hereditary Breast Cancer
There is increasing evidence suggesting that short telomeres and subsequent genomic instability contribute to malignant transformation. Telomere shortening has been described as a mechanism to explain genetic anticipation in dyskeratosis congenita and Li-Fraumeni syndrome. Since genetic anticipation...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145621/ https://www.ncbi.nlm.nih.gov/pubmed/21829373 http://dx.doi.org/10.1371/journal.pgen.1002182 |