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The Effect of Macromolecular Crowding, Ionic Strength and Calcium Binding on Calmodulin Dynamics

The flexibility in the structure of calmodulin (CaM) allows its binding to over 300 target proteins in the cell. To investigate the structure-function relationship of CaM, we combined methods of computer simulation and experiments based on circular dichroism (CD) to investigate the structural charac...

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Detalles Bibliográficos
Autores principales: Wang, Qian, Liang, Kao-Chen, Czader, Arkadiusz, Waxham, M. Neal, Cheung, Margaret S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145654/
https://www.ncbi.nlm.nih.gov/pubmed/21829336
http://dx.doi.org/10.1371/journal.pcbi.1002114