Frequency Domain Analysis Reveals External Periodic Fluctuations Can Generate Sustained p53 Oscillation

p53 is a well-known tumor suppressor protein that regulates many pathways, such as ones involved in cell cycle and apoptosis. The p53 levels are known to oscillate without damping after DNA damage, which has been a focus of many recent studies. A negative feedback loop involving p53 and MDM2 has bee...

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Detalles Bibliográficos
Autores principales: Shin, Yong-Jun, Hencey, Brandon, Lipkin, Steven M., Shen, Xiling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145758/
https://www.ncbi.nlm.nih.gov/pubmed/21829536
http://dx.doi.org/10.1371/journal.pone.0022852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145758/
https://www.ncbi.nlm.nih.gov/pubmed/21829536
http://dx.doi.org/10.1371/journal.pone.0022852

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