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Frequency Domain Analysis Reveals External Periodic Fluctuations Can Generate Sustained p53 Oscillation
p53 is a well-known tumor suppressor protein that regulates many pathways, such as ones involved in cell cycle and apoptosis. The p53 levels are known to oscillate without damping after DNA damage, which has been a focus of many recent studies. A negative feedback loop involving p53 and MDM2 has bee...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145758/ https://www.ncbi.nlm.nih.gov/pubmed/21829536 http://dx.doi.org/10.1371/journal.pone.0022852 |